Aromatase Inhibitors: Uses, Dosage, Side Effects, Interactions

Mrs. X, was a 56 year old Caucasian, married homemaker who lived with her husband and 16 year old daughter. Her medical https://www.allisonacademy.com/gonarex-5000-iu-ronak-a-comprehensive-overview-3/ and surgical history was significant for hypothyroidism, diverticulosis and allergic rhinitis, Cesarian-section and face lift. Her past psychiatric history was important for two previous psychiatric treatments.

Arimidex vs. Other PCT Options

• Although extra-gonadal estrogen is synthesized in small amounts, its concentration is high enough to exert a biological effect locally 29.
• AROMATEST offers men a natural alternative to medically prescribed aromatase inhibitors.
• These formulations can also be used to treat other disorders involving endometriosis and ovarian cancer which are caused by excessive estrogen production.
• The effect of estrogen replacement therapy on Ang II levels is unclear.

Not only that, but aromatase inhibitors are even prescribed alongside medically prescribed testosterone replacement therapy (TRT) to help mitigate the side effects of a rise in estrogen levels. Estrogen modulators, sometimes called anti-estrogens or estrogen blockers, are a group of compounds that suppress the body’s estrogen production or block estrogen from binding to receptors. Multiple types of estrogen blockers exist, including selective estrogen receptor modulators (SERMs) such as tamoxifen and aromatase inhibitors (AIs) such as anastrozole. Exemestane is a medication used to treat breast cancer in postmenopausal women. It works by blocking the production of estrogen, a hormone that can promote the growth of certain types of breast cancer cells.

The women who took Aromasin also lived 68% longer without developing cancer in the other breast compared with the women who kept taking tamoxifen. Researchers found that women who switched to Aromasin from tamoxifen were more likely to stay cancer-free than those who kept taking tamoxifen. However, over time, there was no difference in the survival rate (how long they lived) in the two groups. So before you start taking the drug, your doctor will order lab tests to check your vitamin D levels. Your doctor will check your bone mineral density before you start and during your treatment with Aromasin. If you already have low bone mineral density, your risk for more bone loss and fractures is higher.

This new Cyclosome® technology allows a form of “Trojan Horse” to deliver prohormones and testosterone boosters to the systemic circulation, circumventing first-pass inactivation in the liver for the very first time. Almost all previous oral capsules and tablets manufactured to increase testosterone including testosterone itself, are involved in the “first pass affect” which renders the active compounds virtually useless. Working these into your diet either as ingredients or supplements (or both) won’t always increase how much testosterone your body produces. However, using these natural aromatase inhibitors for men will increase how much testosterone is available for your body to use. One such piece of research happened at Tulane University in New Orleans in 2012.

Natural Aromatase Inhibitors for Men – Conclusion

The women must have tried tamoxifen, and the drug didn’t work or stopped working. Like tamoxifen, these drugs are more often used to treat hormone receptor-positive breast cancer than to lower breast cancer risk. Chrysin Plus DIM Aromatase Inhibitor Cream is also a natural estrogen blocker for both men and women. The anti estrogen ingredients help the body process hormones correctly, promoting a healthier hormone balance.

Anastrozole, a selective aromatase inhibitor, is available as a 1 mg tablet, which is to be taken orally once a day, with or without food. No dose adjustment is necessary for patients with renal or liver impairment or elderly patients. The original purpose of Arimidex is to treat breast cancer in post-menopausal women where the cancer is being promoted by estrogen, where Arimidex can minimize the amount of estrogen in the body and slow or stop the growth of breast cancers. Like many drugs, Arimidex is sometimes prescribed off-label (which means the FDA does not approve its use) to men who are on testosterone replacement therapy (TRT) to lower estrogen levels.

Exemestane is typically only prescribed for women who have gone through menopause and who have hormone receptor-positive tumors (meaning their tumors are responsive to hormones). It is typically used in women who have already undergone treatment with tamoxifen, a similar hormone therapy drug, for several years. Arimidex blocks the aromatase enzyme, which is a critical part of the estrogen biosynthesis process – without this enzyme, the production of estrogen can be stopped. Still, Arimidex and other aromatase inhibitors do so on a much more systemic level compared with SERM drugs, which only affect particular parts of the body that they are targeted to. The angiotensinogen mRNA is expressed in several body organs including the heart, vascular system, kidneys, and adrenal glands 79. The levels of angiotensinogen are generally higher in premenopausal women than in postmenopausal women 79.

In addition to the approved uses listed above, Aromasin may be used off-label for other types of breast cancer. Off-label drug use is when a drug that’s approved for one use is used for a different one that’s not approved. And you may wonder if Aromasin is used for certain other conditions. The other two studies were single-arm studies, meaning that all the women received Aromasin for breast cancer. The tests your doctor gives you will help determine what type of breast cancer you have, where it is, if it’s spread, and the type of treatment you need. It’s not known how often heart problems occur when Aromasin is used to treat advanced breast cancer.

Meanwhile, the detection of high amounts of estrogens in the male semen can be explained by the expression of aromatase in different testicular cells. Carreau et al. reported the presence of physiologically active aromatase in Leydig cells, Sertoli cells, spermatocytes, spermatids, and ejaculated spermatozoa in males 116. Thus, there are two major arms in the RAAS that has opposing actions.

In addition, third-generation AIs outperform the first- and second-generation AIs in terms of clinical benefit and near-complete specificity in clinical application 155. However, long-term adverse effects of these drugs, such as skeletal and cardiovascular problems, must be carefully monitored 155. Gonadally and extragonadally-driven estrogens share the same chemical structure and biological activity, but differ in their metabolic pathways of synthesis 29. Extra-gonadal estrogens are produced when C19 precursors are supplied to any tissue that expresses aromatase 29. Noteworthy, aromatase is primarily produced by ovarian granulosa cells in premenopausal women and adipose cells in postmenopausal women 114.